organs/tissues) via material balances on homogeneous compartments. The combined model accounts for skin transport via diffusion equations, and absorption and distribution in the rest of the body (i.e. The skin model features three strata: stratum corneum, viable epidermis, and dermis, which have a major impact on the absorption, distribution, and metabolism of transdermal drugs. This is achieved by an innovative combination of the physiologically-based compartmental approach with Fick’s laws of diffusion. This paper proposes a model for the study and prediction of drug transport through skin and the following distribution to human body. ABSTRACT: There is a significant hype in the medical sector for the transdermal administration of drugs as it allows achieving a combination of multiple advantages: non-invasive procedure, pain avoidance, no first-pass hepatic metabolism, and induction of sustained plasma levels.
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